Name some situations in which the endogenous ligand of a new biological target may not serve as a good lead compound
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Advantages
• You do not have to be creative.
• You do not have to understand what causes the disease state.
• You can test whatever becomes available.
• You may get hits with compounds that would not have been tested in a rational approach because structures are unrelated to what you think should be important
Disadvantages
• There are an almost infinite number of possibilities.
• You may be testing compounds completely unrelated to the biological system that is important.
• Time and expense may be excessive.
• You do not have to be creative.
• You do not have to understand what causes the disease state.
• You can test whatever becomes available.
• You may get hits with compounds that would not have been tested in a rational approach because structures are unrelated to what you think should be important
Disadvantages
• There are an almost infinite number of possibilities.
• You may be testing compounds completely unrelated to the biological system that is important.
• Time and expense may be excessive.
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