Question

Name the base change and the amino acid change,responsible for sickle cell anaemia

Answer 1

Glutamic acid is replaced by valine at the 6th position of the beta globin chain of haemoglobin

so the 
base = valine
acid= Glutamic acid

first one is Glutamic acid and second is valine

Answer 2

The base change and the amino acid change, responsible for sickle cell anaemia are valine and glutamic acid respectively.

• Sickle cell anaemia is a change in the shape of red blood cells and results in a sickle-like shape in place of the natural biconcave shape.
• It occurs due to the substitution of valine amino acid with glutamic acid.
• It is a mutation that occurs in the 6th position of a beta-globin chain of haemoglobin.
• The gene responsible for sickle cell anaemia is found on chromosome 11.
• Valine is a basic amino acid while glutamic acid is an acidic amino acid.

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