Name the enzyme and coenzyme used for oxidative decarboxylation of pyruvate.
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Answer:
The oxidative decarboxylation of pyruvate (oxidative = NADH produced), is a reaction that occurs AFTER glycolysis in the mitochondrion, but BEFORE the Citric Acid Cycle. ... Five coenzymes are involved - TPP (thiamine pyrophosphate), NAD, FAD, Coenzyme A, and lipoic acid
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Explanation:
This oxidative decarboxylation of pyruvic acid is catalyzed by the enzyme complex - pyruvate dehydrogenase. The term complex is used because three enzymes and five coenzymes are involved. The specific enzyme, pyruvate dehydrogenase contains thiamine pyrophosphate (TPP) as a coenzyme.
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