nanofabricated devices to separate and interrogate dna
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I am not sure what you need as the answer, so I am giving a general answer about the Nanofabricated devices.
Nano-fabricated devices are embodiment that are used for the for extraction, separation, for removing, and or for concentrating the nucleic acids and other biological substances from given samples like blood, saliva, cell lysates, etc.
These devices contain arrayed pillars usually made of silicon dioxide, that form the extraction columns and are arranged in microfluidic devices. The gaps in between these pillars range from tens of nano meters to hundreds of nano meters. The nucleic acids are large molecules and using these nano fabricated devices increases the adsorption kinetics and in turn improves the extraction process. The nucleic acids will get adsorbed onto the polymer coatings present on the surface of the pillar. When they are placed in a different running buffer, the nucleic acids can be eluted from the surface layers.
Nano-fabricated devices are embodiment that are used for the for extraction, separation, for removing, and or for concentrating the nucleic acids and other biological substances from given samples like blood, saliva, cell lysates, etc.
These devices contain arrayed pillars usually made of silicon dioxide, that form the extraction columns and are arranged in microfluidic devices. The gaps in between these pillars range from tens of nano meters to hundreds of nano meters. The nucleic acids are large molecules and using these nano fabricated devices increases the adsorption kinetics and in turn improves the extraction process. The nucleic acids will get adsorbed onto the polymer coatings present on the surface of the pillar. When they are placed in a different running buffer, the nucleic acids can be eluted from the surface layers.
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