Normally, the only fuel for the brain is glucose. But during the starvation, the brain derives
most of its energy from ketone bodie rather than fatty acids which are available in plenty. What
could be the reason for it?
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Fatty acids do not serve as fuel for the brain, because they are bound to albumin in plasma and so do not traverse the blood-brain barrier. In starvation, ketone bodies generated by the liver partly replace glucose as fuel for the brain.
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