Notch influences the survival of neural precursors and differentiating neurons in themammalian brain. Conditional knockdown of notch1 and notch3 in vivo results in increased apoptosis of large number of neural pro-genitors and differentiating neurons [67]. Notch can also promote apoptosis in the mammalian nervous system. Notch knockouts have been reported to show reduced apoptosis of early neural pro-genitors [68]
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