nucleosome and polysome difference
Answers
●A polyribosome (or polysome) is a complex of an mRNA molecule and two or more ribosomes that act to translate mRNA instructions into polypeptides.
●Originally coined "ergosomes" in 1963, they were further characterized by Jonathan Warner, Paul M. Knopf, and Alex Rich.
Polysome breakdown is a frequent cytoplasmic manifestation of hepatocellular toxicity when transcription is inhibited. Polysomes are aggregates of numerous ribosomes that are in the process of actively translating mRNA into protein. By light microscopy polysomes appear as basophilic cytoplasmic granules, but are extremely labile during postmortem change in the liver. As a result, polysomes are observed only in rapidly fixed liver tissue. Polysome breakdown appears as the loss of basophilic cytoplasmic granules, but its attribution to hepatotoxicity can only be confirmed with rapid fixation such as perfusion fixation.