obesity and hyperglycemia leads to insufficiency of which hormone ??
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Obesity has been identified as a major causative factor for the insulin resistance and hyperglycemia associated with diabetes.
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Obesity-induced diabetes is related to decreased insulin-signaling via IR and its downstream proteins. A chronic inflammatory state seems to play a pivotal role in the insulin resistance. Differences do exist in the mechanisms of insulin resistance between liver, muscle, and adipocyte
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