oestrogen and progesterone antagonistic or synergistic
Answers
Answer:
The daily administration of.oestrogen to immature
female chickens induces oviduct growth, cell division
and the differentiation of epithelial cells into tubular
gland cells which synthesize a number of egg-white
proteins . Simultaneous administration of
progesterone antagonizes the oestrogen-induced tissue
growth, cell division, tubular gland cell formation and
subsequent egg-white protein synthesis .
The situation is somewhat different when oestrogenwithdrawn immature chickens are treated in a
similar manner. Both oestrogen and progesterone are
capable of independently inducing the synthesis of
ovalbumin in preexisting tubular gland cells. Furthermore, oestrogen and progesterone act synergistically
on the synthesis of these proteins although progesterone
still antagonizes the oestrogen-induced synthesis of
new DNA.
Since progesterone-induced inhibition of cytoplasmic
oestrogen receptor replenishment has been implicated
in progesterone antagonism of oestrogen induced
growth in the immature rat uterus , we have
investigated the effect of progesterone on the oestrogeninduced changes in oestrogen receptor concentration
and DNA polymerase activity in the oestrogen-withdrawn immature chick oviduct.
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