Question

On the contrary, cancer cells have different capabilities including proliferative signaling, escaping growth suppressors, resisting cell death, immortality, angiogenesis followed by invasion metastasis

Answer 1

A final critical point would be whether the description of the hallmarks has led to translational benefit in the clinic .In Hallmarks II, various drug categories were linked to their targeted hallmark, but many have proved to only be effective for a limited time or within limited settings.

Answer 2

Explanation:

Tumor cells may evade tumor suppressors by genetic and epigenetic mechanisms. Genetic mechanisms include chromosomal deletion, mutation and inactivation or loss of upstream or downstream effectors. Epigenetic evasion includes DNA methylation, and histone methylation and acetylation.