One of the human congenital tumour showing evidence of genomic imprinting is
a)Wilm's tumour b) Retinoblastoma c)Hodgkin's lymphoma d)Osteosarcoma
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Answer:
Wilm's tumour
Explanation:
Wilm's tumour is a human congenital disease, which is also called as nephroblastoma.
In healthy cells, maternal H19 and paternal IGF2 is expressed. Many upstream sites of H19 gene in human are methylated in paternal allele but are they are unmethylated in maternal allele. Due to loss of imprinting, the maternal chromosome reverts back to or shifts to a paternal epigenotype showing methylation of H19 promoter in the upstream element. IGF2 turned on and H19 turned off results in increased cell growth in Wilm's Tumour.
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