origin of quantitative diagnosis?
Answers
Bone Biopsy
Biopsy of bone and the microscopic analysis of undercalcified sections after double tetracycline labeling provide definitive and quantitative diagnosis of renal bone disease.24 To standardize reports on bone histology, the Kidney Disease: Improving Global Outcomes (KDIGO) CKD-MBD work group initialized the TMV classification, an assessment of turnover (T), mineralization (M), and bone volume (V).1 Bone mineralization is assessed by the administration of two different tetracyclines spaced apart (e.g., tetracycline 500 mg three times daily for 2 days followed by a 10-day interval, then demeclocycline 300 mg three times daily for 3 days) and biopsy 4 days later; the quantitation of bone mineralization rate is achieved by measuring the distance between the two fluorescent tetracycline bands.
Answer:
Bone Biopsy
Biopsy of bone and the microscopic analysis of undercalcified sections after double tetracycline labeling provide definitive and quantitative diagnosis of renal bone disease.24 To standardize reports on bone histology, the Kidney Disease: Improving Global Outcomes (KDIGO) CKD-MBD work group initialized the TMV classification, an assessment of turnover (T), mineralization (M), and bone volume (V).1 Bone mineralization is assessed by the administration of two different tetracyclines spaced apart (e.g., tetracycline 500 mg three times daily for 2 days followed by a 10-day interval, then demeclocycline 300 mg three times daily for 3 days) and biopsy 4 days later; the quantitation of bone mineralization rate is achieved by measuring the distance between the two fluorescent tetracycline bands.