Question

outline the stages of carcinogenesis

Answer 1

1st stage- Initiation

Rapid onset
Irreversible DNA damage
Modification of the biological potency of the affected cell

2nd stage- Promotion
Slow development (latency period: 5-30 years!)
Reversible
Non-additive

3rd stage- transformation
Further mutations
Conversion of a pre-neoplastic cell into a cell with malignant phenotype (uncontrolled growth, genetic instability)
Inheritance of damaged genetic material to daughter cells