Oxaloacetate is a precursor of
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Two of the TCA cycle intermediates, α-ketoglutarate and oxaloacetate serve as precursor metabolites for the biosyntheses of amino acids and nucleotides. The most important anaplerotic pathways are carbon dioxide fixation by either pyruvate carboxylase or PEP carboxylase, leading to the formation of oxaloacetate
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Oxaloacetate is a precursor of the biosynthesis of amino acids and nucleotides.
- It is a key node in the production of lysine
- Its chemical formula is c4h4o5
- It is also a potent inhibitor of complex
- It forms in different ways in nature
- basic principle is upon the oxidation of L- malate in the citric acid cycle in the presence of malate dehydrogenase
- It can also produce by condensation of pyruvate with carbonic acid in the presence of hydrolysis of ATP.
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