oxetane ring opening is much slower then oxirane..why?
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Oxetane undergoes hydrolysis 3-orders of magnitude slower than oxirane under alkaline conditions. The plausible explanation could be the following: in the case of 3-membered oxirane more strain is released in the transition state, which leads to a lower activation energy than in 4-membered rings.
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Oxetane undergoes hydrolysis 3-orders of magnitude slower than oxirane under alkaline conditions. The plausible explanation could be the following: in the case of 3-membered oxirane more strain is released in the transition state, which leads to a lower activation energy than in 4-membered rings.
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