oxidative cleavage of [Pb(OAc)4 and HIO4
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Periodic acid (HIO4) and lead tetraacetate (Pb(OAc)4) are the most common reagents used for glycol cleavage, processes called the Malaprade reaction and Criegee oxidation, respectively. These reactions are most efficient when a cyclic intermediate can form, with the iodine or lead atom linking both oxygen atoms.
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