Question

P53 compound heterozygosity in a severely affected child with li-fraumeni syndrome

Answer 1

p53 compound heterozygosity in a severely affected child with Li-Fraumeni syndrome. ... In some kindreds, the genetic abnormality associated with this cancer phenotype is a heterozygousgermline mutation in the p53tumor suppressor gene.

Answer 2

p53 compound heterozygosity in a severely affected child with Li-Fraumeni syndrome. ... The Li-Fraumeni Syndrome (LFS) is a rare, dominantly inherited syndrome that features high risk of cancers in childhood and early adulthood.
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