Question

Pax8 promotes tumor cell growth by transcriptionally regulating e2f1 and stabilizing rb protein

Answer 1

Auxins (plural of auxin /ˈɔːksɪn/) are a class of plant hormones (or plant growth regulators) with some morphogen-like characteristics. Auxins have a cardinal role in coordination of many growth and behavioral processes in the plant's life cycle and are essential for plant body development. Auxins and their role in plant growth were first described by the Dutch biologist Frits Warmolt Went. Kenneth V. Thimann was the first to isolate one of these phytohormones and determine its chemical structure as indole-3-acetic acid (IAA). Went and Thimann co-authored a book on plant hormones, Phytohormones, in 1937.

Answer 2

Answer:

The retinoblastoma protein (RB)-E2F1 pathway has a central role in regulating the cell cycle. ... Therefore, our results suggest that, in cancer, frequent and persistent expression of PAX8 is required for cell growth control through transcriptional activation of E2F1 expression and upregulation of the RB-E2F1 pathway.