Peptide stability in drug development. ii. effect of single amino acid substitution and glycosylation on peptide reactivity in human serum.
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by MF Powell · 1993 · Cited by 188 · Related articles
10, No. 9, 1993. Research Article. Peptide Stability in Drug Development. II. Effect of Single. Amino Acid Substitution and Glycosylation on Peptide. Reactivity in Human Serum.
10, No. 9, 1993. Research Article. Peptide Stability in Drug Development. II. Effect of Single. Amino Acid Substitution and Glycosylation on Peptide. Reactivity in Human Serum.
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The determination of peptide stability in human serum (HS) or plasma constitutes a powerful screening assay for eliminating unstable peptides from further development. ... Peptides that were protected by d-amino acids at both termini were found to be more stable than predicted, based on additivity of single substitutions.
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