Question

Peptide stability in drug development. ii. effect of single amino acid substitution and glycosylation on peptide reactivity in human serum.

Answer 1

by MF Powell · 1993 · Cited by 188 · Related articles

10, No. 9, 1993. Research Article. Peptide Stability in Drug Development. II. Effect of Single. Amino Acid Substitution and Glycosylation on Peptide. Reactivity in Human Serum.

Answer 2

The determination of peptide stability in human serum (HS) or plasma constitutes a powerful screening assay for eliminating unstable peptides from further development. ... Peptides that were protected by d-amino acids at both termini were found to be more stable than predicted, based on additivity of single substitutions.