Question

Phenobarbital synthesis from benzyl chloride

Answer 1

Answer:

N-Substituted and N,N′-disubstituted benzyl derivatives of barbital, phenobarbital, and amobarbital have been synthesized by the use of a strongly basic anion-exchange resin. The barbiturate is first absorbed on the resin and the resin then agitated mechanically with an ethanol solution of benzyl chloride. The reaction proceeds at room temperature. The yields in all cases ranged from 50 to 80 per cent.

Explanation:

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