Question

physical interactions that determine the properties of proteins

Answer 1

The physical properties that determine the properties of proteins include :


1. EXCLUDED VOLUME

This is repulsive interaction due to mutual impenetrability between two protein molecules.

Excluded volume is usually described as representing approximately four times volume of protein molecule.


2. ELECTROSTATIC INTERACTIONS

These are long range interactions which occur between charged groups separated by a distance comparable to the dimension of the protein.


3. VAN DER WAALS FORCE

They are attractive and active at shorter distances compare to electrostatic forces.

It strongly depends on the shape of the interacting forces.


4. Hydrogen bonding

This is a polar attractive interaction that occurs when hydrogen atom is shared between generally two electronegative atoms.


5. SOLVATION FORCES

These arise from the ordering of solvent molecules around the protein molecule and act over 10to 5solvent molecule diameters.

Hydration forces refer to the Solvay ion interaction of surfaces containing polar charged groups.

Answer 2

Proteins rarely act alone as their functions tend to be regulated. Many molecular processes within a cell are carried out by molecular machines that are built from a large number of protein components organized by their PPIs. These interactions make up the so-called interactomics of the organism, while aberrant PPIs are the basis of multiple aggregation-related diseases, such as Creutzfeldt–Jakob, Alzheimer's diseases, and may lead to cancer.