Question

Principle for preparation of acetanilide

Answer 1

Principle : Acetanilide is synthesized from aniline by acetylating it with acetic anhydride in presence of glacial acetic acid. Aniline reacts with acetic anhydride to form Acetanilide by nucleophilic substitution reaction and the reaction is called acetylation.

Answer 2

Preparation of Acetanilide

Acetanilide is prepared from aniline when it reacts with acetic anhydride/glacial acetic acid in the presence of zinc dust. A mixture of aniline, glacial acetic acid, acetic anhydride and zinc dust is refluxed under anhydrous condition and then poured the mixture into ice cold water to get acetic anhydride precipitate.

C6H5NH2 + (CH3CO)2O ----------> C6H5NHCOCH3 + CH3COOH