Science, asked by swethasureddy1667, 1 year ago

Process for the preparation of tapentadol

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Answered by SmartCutiePie

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The present invention refers to a new process for the synthesis of tapentadol comprising the quantitative resolution of the racemic mixture (V) to obtain the stereoisomer of (S)-3-(dimethylamino)-2-methyl-l-(3-nitrophenyl)-propan-l-one ( VII) according to the Scheme 2 below (V, VI, VII) Scheme 2

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