Process of Blood Clotting
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The coagulation cascade is a complex chemical process that uses as many as 10 different proteins (called blood clotting factors or coagulation factors) found in plasma in the blood. Put simply, the clotting process changes blood from a liquid to a solid at the site of an injury. Here’s how the process works:
1) Injury
A small tear in a blood vessel wall (for example, from a cut on the skin or an internal injury) causes bleeding.
2) Vessel constriction
To control blood loss the blood vessel narrows, thus limiting blood flow through the vessel.
3) Platelet plug
In response to the injury, tiny cells in the blood called platelets are activated. The platelets stick to one another and to the wound site to form a plug. The protein von Willebrand factor helps the platelets stick to each other and to the blood vessel wall.
4) Fibrin clot
Next, clotting factor proteins trigger production of fibrin, a strong, strand-like substance that forms a fibrin clot, a mesh-like net that keeps the plug firm and stable. Over the next several days to weeks, the clot strengthens and then dissolves as the wounded blood vessel wall heals.
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Blood clotting is a process in which blood is converted into a gelatinous substance that actually hardens . The aim to stop the flow of blood from a vessel.The formation of the clot is the result of enzymatic reactions that are triggered
upon injury.
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