Protein ultrafiltration: theory of membrane fouling and its treatment with immobilized proteases
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To circumvent the severe flux losses encountered during ultrafiltration of macromolecular solutions, enzymes were immobilized on the membranes to hydrolyze the deposited solute molecules. This resulted in 26 to 78% flux enhancements, averaged over a 20 hr period, during a daily run. A mathematical model was developed to explain gel formation and the action of the enzyme precoat on the membrane surface.
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