Q.No.1 Multiple Choice Question (Mark 24)
1. Which of the following factors is not responsible for the denaturation of proteins?
(a) Heat
(b) Charge
(c) PH change
(d) Organic solvents
3. Which of the following amino acid is an alpha helix terminator
(a) Cysteine
(b) Alanine
(c) Proline
(d) Isoleucine
4. The secondary structure is primarily maintained by
(a) Van der Waals force
(b) Hydrogen bond
(c) Ionic bond
(d) Hydrophobic bonds
6. The amyloid protein deposition associated with Alzheimer’s disease is composed of
(a) Alpha helix
(b) Beta pleated sheets
(c) Beta bends
(d) Tertiary structure
8. Which of the following statements are true regarding tertiary structure of proteins
(a) 3 dimensional structure of a protein
(b) It is the biologically active conformation
(c) Primary structure of protein determines the tertiary structure
(d) All of these
6. Which of the following amino acid has buffering capacity
(a) Tryptophan
(b) Cysteine
(c) Histidine
(d) Arginine
7. A mutation has changed an isoleucine residue of a protein to Glutamic acid, which statement
best describes its location in a hydrophilic exterior
(a) On the surface since it is hydrophilic in nature
(b) Inside the core of the protein since it is hydrophobic in nature
(c) Anywhere inside or outside
(d) Inside the core of protein since it has a polar but uncharged side chain
8. Choose the incorrect statement out of the followings
(a) Only L amino acids are found in the biological system
(b) Glycine is optical inactive
(c) Tyrosine is a modified amino acid
(d) Seleno cysteine is 21st amino acid
9. All of the below mentioned amino acids can participate in hydrogen bonding except one
(a) Serine
(b) Cysteine
(c) Threonine
(d) Valine
10. The greatest buffering capacity at physiological pH would be provided by a protein rich
in which of the following amino acids?
(a) Serine
(b) Cysteine
(c) Alanine
(d) Histidine
11. Which of the characteristics below apply to amino acid Glycine?
(a) Optically inactive
(b) Hydrophilic, basic and charged
(c) Hydrophobic
(d) Hydrophilic, acidic and charged
12. A protein has a tertiary structure formed by interactions between the side chains of the
following pairs of amino acids. For each pair, identify the strongest type of interaction
between these amino acids.
(a) aspartic acid and lysine
(b) Phenylalanine and alanine
(c) Serine and lysine
(d) Two cysteines
Answers
Answer:
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The correct multiple choice of the following question is as follow -
1. Charge - Heat, pH change, and organic solvent causes the denaturation of proteins. Denaturation of protein is the change of the secondary, tertiary, and quaternary structure of protein into a simpler form.
3. Alanine - Since alanine is uncharged, therefore, it forms an alpha terminator, whereas all others are charged hence do not form an alpha helix.
4. Van der Waals force - Van der Waals force is the distance-dependent interaction between atoms and molecules. This force is used for the maintenance of the secondary structure of the protein.
6. Beta bends - The beta-amyloid protein involved in Alzheimer's disease is beta-amyloid 42 and is very toxic.
8. All of these - Three-dimensional structure of a protein , biologically active conformation and the primary structure of a protein determine the tertiary structure all these are true.
6. Histidine - Histidine is an alpha-amino acid, so it has a buffering capacity, whereas all others do not have.
7. Inside the core of protein since it is hydrophobic in nature - The hydrophilic exterior is inside the core of the protein.
8. Only L amino acids are found in the biological system - It is so far noticed that only a levo isomer of the amino acid exists in the biological system.
9. Valine - Serine, Cysteine, Threonine all can form hydrogen bonds excepts for Valine.
10. Histidine - Since histidine is basic, therefore it has the greatest buffering capacity at physiological pH.
11. Optically inactive - Glycine is the only amino acid in nature that is optically inactive.
12. Aspartic acid and lysine - Since aspartic acid is an acid, and lysine is a base. It forms an ionic bond and it is strongest among all the interactions.