Question

Q3) MOA of 5-Fluorouracil is
Dihydrofolate reductase inhibitor
O Topoisomerase inhibitor
Thymidylate synthase inhibitor
O Inosin monophosphate inhibitor​

Answer 1

Answer:

MOA of 5-Fluorouracil is

Option C Thymidylate synthase inhibitor

5-FU acts in several ways, but principally as a thymidylate synthase (TS) inhibitor. Interrupting the action of this enzyme blocks synthesis of the pyrimidine thymidylate (dTMP), which is a nucleotide required for DNA replication.