range of outcomes by pointes
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Clinical outcomes range from asymptomatic, self-terminating arrhythmias to ventricular fibrillation resulting in cardiac arrest. The definitive emergency therapy for torsade de pointes is overdrive pacing; cautious isoproterenol administration can also be used.
Answer:
ESTIMATING OVERVIEW: UNDERSTANDING THE RANGE OF POSSIBLE OUTCOMES
The problem with most estimates today is that they are single point numbers with no context as to how optimistic or pessimistic they are. Then they normally have one or more safety factors applied without any real overarching goal other than not going “over budget,” and no real basis for the factors applied.
By Douglas D. Plummer, PMP
Everyone who has ever prepared a quote or Basis of Estimate (BOE) for a proposal has probably found themselves in the position of padding an estimate received from their team to prevent an overrun position down the road during execution. Let’s take a closer look at how we can get a better handle on the validity of the original quote, and how much of a safety factor we should add based on our overall program objectives and program constraints such as the Price-to-Win (PTW).
First let’s take a quick look at some of the methods we can use to develop the initial estimate.