Reaction between isocyanate and carboxylic acid in presence of triflic acid
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Answer:
The chemical transformation of the carboxylic acid functional group into the corresponding carboxylic amide (peptide) is a very important reaction in bioorganic chemistry. The synthesis of amides by the reaction of a carboxylic acid with an isocyanate has received little attention.
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Explanation:
☑️ Ionic liquids (ILs) based on 1,3-dialkylimidazolium and ammonium have been used as an efficient reaction media in the amidation of several carboxylic acids with isocyanates.
The method has wide applicability, and the protocol is mild and efficient compared to the existing methods based on conventional solvents.
Proper 'design' of the ILs allows us to obtain amides in good to excellent yields. In this reaction, both aromatic and aliphatic isocyanates could be used.
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