reaction of chlorobenzyn with
respect to sulphonation
Answers
Answer:
Ok batata ho thodi der mein
Answer:
The reaction of chlorobenzene with sulphuric acid is shown as in the diagram.
solution.
Explanation:
invention relates to novel 1-acyl-4-aliphatylaminopiperidine compounds of formula (I), in which R1 is a benzoyl, naphthoyl or cycloalkanoyl radical which is unsubstituted or substituted by lower alkyl, lower alkoxy, halogen and/or trifluoromethyl; R2 is cycloalkyl or a phenyl or naphthyl radical which is unsubstituted or substituted by lower alkyl, lower alkoxy, halogen, nitro, cyano and/or trifluoromethyl; R3 and R4 together are lower alkylene or aza-, oxa- or thia-lower alkylene; or R3 is lower alkyl, lower alkoxy-lower alkyl, di-lower alkylamino-lower alkyl or a radical of the formula -(CH2)n-C(=O)-R5 (Ia); and R4 is hydrogen, lower alkyl or a radical of the formula -(CH2)n-C(=O)-R5 (Ia); R5 is (i) hydrogen, alkyl or alkyl which is substituted by halogen, lower alkoxy, amino or amino substituted by lower alkyl, amino-lower alkyl, mono- or di-lower alkylaminoalkyl, lower alkanoyl, lower alkoxycarbonyl or lower alkylene or aza-, oxa- or thia-lower alkylene, (ii) hydroxyl, cycloalkoxy, lower alkoxy or lower alkoxy which is substituted by lower alkoxy, amino or amino substituted by lower alkyl, amino-lower alkyl, mono- or di-lower alkylamino-alkyl, lower alkanoyl, lower alkoxycarbonyl or lower alkylene or aza-, oxa- or thia-lower alkylene, or (iii) amino or amino substituted by lower alkyl, cycloalkyl, amino-lower alkyl, mono- or di-lower alkylaminoalkyl, lower alkanoyl, lower alkoxycarbonyl or lower alkylene or aza-, oxa- or thia-lower alkylene; X1 is methyelene, ethylene, a direct bond, a free or ketalized carbonyl group or a free or etherified hydroxymethylene group and n is 0 or 1, and their salts, processes for the preparation of the compounds according to the invention, pharmaceutical compositions containing these and their use as pharmaceutical active ingredients.
Classifications
C07D211/58 Nitrogen atoms attached in position 4
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EP0783490A1
European Patent Office
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Other languagesGermanFrenchInventorSilvio OfnerSiem Jacob VeenstraCurrent Assignee Novartis Pharma GmbH
Worldwide applications
1995 DE EP CA HU PT US MX WO AU JP DK AT ES 1997 NO FI
Application EP95933394A events
1994-09-30
Priority to CH296694
1995-09-19
Application filed by Novartis Pharma GmbH, Ciba Geigy AG, Novartis AG
1997-07-16
Publication of EP0783490A1
2002-02-06
Application granted
2002-02-06
Publication of EP0783490B1
2015-09-19
Anticipated expiration
Status
Expired - Lifetime
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