Receptor , receptor interacts with cytoskeleton, lipid, membrane protein which has higher diffusion coeficient
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The composition and organization of the plasma membrane are both highly complex and ever-changing. The modes by which proteins move in the plane of the membrane provide insights into the molecular interactions between these proteins and neighboring membrane proteins, membrane lipids, the underlying cytoskeleton, and counter-receptors on cells or other structures in the extracellular environment. Over the past several decades, investigators have developed increasingly sophisticated methods for probing the dynamics of membrane proteins, and, in so doing, have helped to define structure–function relationships among membrane receptors, counter-receptors, and structural proteins.
Membrane-associated proteins comprise a large subset of all proteins synthesized by mammalian cells. Understanding how these proteins move and interact with one another in their native environment is essential to understanding their cellular function. For example, regardless of their intrinsic affinity for binding to each other, two proteins expressed on the plasma membrane may have little chance for interaction if their positions are fixed at random locations, unless the protein concentration is very high. With slow random diffusion of both proteins, the opportunity for interaction increases. With directed movement of one or both proteins toward a membrane landmark, or with confinement or corralling of the proteins in specific sites (such as focal adhesions or membrane microdomains), the opportunities for interaction increase further. It is in this context that the diffusion modes and kinetics of membrane proteins direct their function