red blood cells live upto
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Normal human red blood cells have an average life span of about 120 days in the circulation after which they are engulfed by macrophages.
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- In the circulation, normal human red blood cells have a lifespan of roughly 120 days before being consumed by macrophages.
- This is a fairly effective mechanism, since macrophages phagocytose around 5 million erythrocytes every second without releasing much hemoglobin into the bloodstream.
- Despite several studies, the exact molecular process by which macrophages detect senescent red blood cells for clearance has remained a mystery.
- Red blood cells age in the circulation and undergo many physicochemical changes.
- A macrophage identification tag based on some of these improvements has been suggested.
- The development of neoantigens on the surface of red cells, exposure to phosphatidylserine, and diminished deformability are the most common explanations for red cell clearance mechanisms.
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