Researchers from a universities of
Bonn and Toulouse on Germany
had identified mutations in three genes
that ought to cause what is
known for "uncombable hair syndrome".These affected tend to
have fair hair those is dry,fizzy
,thin and resistant to be brushed or combed.
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Answers
gene discovered
Team under the leadership of the University of Bonn finds mutations in three genes that lead to uncombable hair
Some children suffer from completely tangled hair, which cannot be combed at all. In German, the phenomenon bears the apt name “uncombable hair syndrome” or even “Struwwelpeter syndrome”. Researchers at the Universities of Bonn and Toulouse have identified mutations in three genes that are responsible for this. Scientists from a total of eight countries were involved in the work. The results were published today in the American Journal of Human Genetics.
Many parents know from their own experience that it is not always easy to comb children’s hair. Yet with patience and nerves of steel, even the toughest of knots can usually be undone.
In the case of “uncombable hair syndrome”, brushes and combs don’t stand even the hint of a chance. Those affected have extremely frizzy, dry, generally light blonde hair with a characteristic shine, which successfully resists any attempt to tame it. These symptoms are most pronounced in childhood and then ease over time. In adulthood, the hair can more or less be styled normally.
Virtually nothing has so far been known about the causes – particularly because the phenomenon is relatively rare. It was described in the specialist literature for the first time in 1973; since then, around one hundred cases have been documented worldwide. “However, we assume that there are much more people affected,” explains Professor Regina Betz from the Institute for Human Genetics at the University of Bonn. “Those who suffer from uncombable hair do not necessarily seek help for this from a doctor or hospital.” Nevertheless, it is known that the anomaly occurs more frequently in some families – it thus appears to have genetic causes.
Betz is a specialist for rare hereditary hair disorders. A few years ago, she was approached at a conference by a British colleague. He had recently examined a family with two affected children. The Bonn-based human geneticist’s interest was piqued. “Via contact with colleagues from around the world, we managed to find nine further children,” she explains. The scientists in Bonn sequenced all the genes of those affected. When comparing large databases, they thus came across mutations in three genes that are involved in forming the hair.
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