Resistant to nucleophilic attack by hydroxyl ions means
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The carbonyl group can also act as a nucleophile. The oxygen of this functional group is electron rich because of its lone pairs and the pi bond. Nucleophilic attack on another molecule by the lone pairs on oxygen or by the pi bond give the same result because the products are resonance structures and thus identical.
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Nucleophilic acyl substitution describe a class of substitution reactions involving ... Thus, chloride ion is a better leaving group than acetate ion. The reactivity of acyl compounds
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