Question

Rodent neurogenesis is similar to the divisions of type i nbs, whereas the more complex lineages of the primate dorsal cortex resemble the type ii nb lineage

Answer 1

Drosophila neuroblasts, the stem cells of the developing fly

brain, have emerged as a key model system for neural stem cell

biology and have provided key insights into the mechanisms

underlying asymmetric cell division and tumor formation. More

recently, they have also been used to understand how neural

progenitors can generate different neuronal subtypes over time,

how their cell cycle entry and exit are coordinated with

development, and how proliferation in the brain is spared from

the growth restrictions that occur in other organs upon

starvation. In this Primer, we describe the biology of Drosophila

neuroblasts and highlight the most recent advances made using

neuroblasts as a model system.