Role of bilirubin in pigmented gallstone formation
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Bilirubin, a yellow pigment derived from the breakdown of heme, is actively secreted into bile by liver cells. Most of the bilirubin in bile is in the form of glucuronide conjugates, which are water soluble and stable, but a small proportion consists of unconjugated bilirubin.
- EXPLANATIIN:- In situations of high heme turnover, such as chronic hemolysis or cirrhosis, unconjugated bilirubin may be present in bile at higher than normal concentrations. Calcium bilirubinate may then crystallize from the solution and eventually form stones.
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Explanation:bilirubin is a chemical that produce when your body breaks down red blood cells
Certain conditions your liver to make too much bilirubin including bilberry cirrhosis biliary tract infection
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