Role of calcium in blood coagulation process,,don't spam...marks-4
Answers
Answer:
To act as an adhesive to hold fibrin monomer and form a polymeric fiber.
Explanation:
Blood clotting is defined as the conversion of blood into gel like substance. The protein responsible for clotting of blood is fibrin. The fibrin monomers polymerise to form fibrin polymers which ultimately form a meshwork on the broken site and prevents loss of blood by forming a clot. The polymerisation of fibrin requires calcium which binds the fibrin monomers with one another so that a fibrin fibre is formed.
Answer:
Arthus discovered in 1890 that calcium was essential in coagulation.
At this stage, it was known that thrombokinase/thromboplastin (factor III) is released by damaged tissues,
reacting with prothrombin (II), which, together with calcium (IV), forms thrombin, which converts fibrinogen into fibrin (I).