Role of chirality in biological activity
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Many compounds are marketed as racemic mixtures even though it is now known that enantiomers can have different biological activities.
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Many compounds are marketed as racemic
mixtures even though it is now known that
enantiomers can have different biological
activities. This can be due to differences in,
for example, protein binding, transport,
metabolism and clearance. Methods
available to determine enantiomers include
chromatography on chiral stationary
phases, the use of chiral additives in the
mobile phase, derivatization to yield
diastereoisomers, chiral detectors, NMR and
enantiomer specific immunoassays. The
advantages of the various methods are
discussed.
Many compounds are marketed as racemic
mixtures even though it is now known that
enantiomers can have different biological
activities. This can be due to differences in,
for example, protein binding, transport,
metabolism and clearance. Methods
available to determine enantiomers include
chromatography on chiral stationary
phases, the use of chiral additives in the
mobile phase, derivatization to yield
diastereoisomers, chiral detectors, NMR and
enantiomer specific immunoassays. The
advantages of the various methods are
discussed.
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