Question

Role of elongator subunit elp3 in drosophila melanogaster larval development and immunity

Answer 1

The Elongator complex has been implicated in several cellular processes, including gene expression and tRNA modification. We investigated the biological importance of the Elp3 gene in Drosophila melanogaster. Deletion of Elp3 results in larval lethality at the pupal stage. During early development, larval growth is dramatically impaired, with progression to the third instar delayed for∼ 24 hr, and pupariation occurring only at day 14 after egg laying. Melanotic nodules appear after 4 days. Microarray analysis shows that stress response …

Answer 2

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Drosophila Elp3 is required for viability. Deletion of the gene thus has a profound effect on larval growth, and Elp3 mutants die at the pupal stage. Moreover, melanotic nodules are formed in third instar larvae, implicating Elp3 in Drosophila innate immune function.