Question

Role of hormones in growth and development of cranio facial status

Answer 1

t has been postulated that most if not nearly all of the growth effects of GH, result from somatomedin.It has been found that GH causes liver to form several small proteins called Somatomedins, that in turn have very potent effect of increasing all aspects of bone growth.     When GH is supplied directly to cartilage condrocytes cultured outside the body, proliferation and enlargement fail to occur.Atleast 4 different types of somatomedins have been isolated  and of this somatomedin-C is most important for functioning of GH.