Question

Role of macrophage in the regulation of bone and blood forming stem cell and progenitor cell migration and development

Answer 1

migration of macrophages into the fracture area, has a major impact on the long term outcome of bone repair.

In fracture healing, skeletal and immune system are closely interacting through common cell precursors and molecular mediators.

Answer 2

In the cycle of bone remodeling, macrophages have a major role in the induction of osteoclastogenic differentiation during the state of resorption. The differentiation of osteoclasts serves as a regulatory step in the formation of osteoblasts and osteocytes.

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