Question

Role of nicotinamide in dna damage, mutagenesis, and dna repair,

Answer 1

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Answer 2

The role of nicotinamide in DNA repair and maintenance of genomic stability is tightly related to its functions as an precursor and a substrate for PARP-1. PARP-1 is a nuclear enzyme which detects DNA damage, binds to DNA single or double strand breaks, and then uses as a substrate to form nicotinamide and ADP-ribose.


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