Question

Roles of tap proteins in antigen and cross-

Answer 1

Cross-presentation is the ability of certain antigen-presenting cells to take up, process and present extracellular antigens with MHC class I molecules to CD8 T cells (cytotoxic T cells). Cross-priming, the result of this process, describes the stimulation of naive cytotoxic CD8+ T cells into activated cytotoxic CD8+ T cells.This process is necessary for immunity against most tumors and viruses that do not readily infect antigen-presenting cells, but rather intracellular tumors and viruses that infect peripheral tissue cells.Cross presentation is also required for the induction of cytotoxic immunity by vaccination with protein antigens, for example, tumour vaccination.


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Answer 2

phagocytic or macropinocytic functions of the cells are ... transporter associated with antigen processing (TAP) into the.