Question

Schwancells macrophages are important cells in leprosy

Answer 1

Leprosy is a chronic granulomatous infection caused by an intracellular organism, Mycobacterium leprae (M. leprae), which primarily affects the skin and peripheral nerves (Walker and Lockwood 2006). ... In addition, M. leprae invades and survives withinmacrophages, dendritic cells andSchwann cells

Answer 2

leprae, a likely immunopathogenic mechanism of damage to Schwann cells and peripheral nerves in leprosy is that infected Schwann cells process and present antigens of M. leprae to antigen-specific, inflammatory, type-1 T cells, and that these T cells subsequently damage and lyse infected Schwann cells.

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