Question

Scientists have several rival theories on the causes of fibromyalgia, a disorder that causes body-wide chronic pain and fatigue. One leading theory holds that conditions such as depression, anxiety, drug use and serotonin deficiency can aggravate or even cause fibromyalgia by interfering with "stage 4," or "deep sleep

Answer 1

This theory is concerned with the function of neuropeptide substance P, which is released in the spinal cord in response to pain and causes nerve endings around the initiating nerves to also become more sensitive to pain. Normally, this mechanism is "reset" during deep sleep. If pain becomes body-wide, however, and the mechanism can not be reset, this process may run out of control.
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