short note on organongenesis
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Organogenesis is the phase of embryonic development that starts at the end of gastrulation and continues until birth. During organogenesis, the three germ layers formed from gastrulation: the ectoderm, endoderm, and mesoderm form the internal organs of the organism.[1]
The cells of each of the three germ layers undergo differentiation, a process where less-specialized cells become more-specialized through the expression of a specific set of genes. Cell differentiation is driven by cell signaling cascades[2]. Differentiation is influenced by extracellular signals such as growth factors that are exchanged to adjacent cells which is called juxtracrine signaling or to neighboring cells over short distances which is called paracrine signaling.[3] Intracellular signals consist of a cell signaling itself (autocrine signaling), also play a role in organ formation. These signaling pathways allows for cell rearrangement and ensures that organs form at specific sites within the organism.[1] The organogenesis process can be studied using embryos and organoids
Part of embryonic development that begins at end of gastrulation and goes on till birth.
During organogenesis three germ layers formed from gastrulation:
ectoderm, endoderm and mesoderm form internal organs of organism.
Cells of every three germ layers undergo differentiation i.e. process where less-specialized cells become more-specialized through expression of specific set of genes.
Cell differentiation is driven by cell signaling cascades.
Differentiation boosted by extracellular signals as growth factors and
exchanged to neighboring cells which is called juxtracrine signaling over short distances.