Question

Sickle cell anaemia is a disease resultant of missense mutation. What codon number in the DNA sequence does the mutation take place? What amino acid substituted the original glutamic acid? This mutation affects which protein chain in the hemoglobin?​

Answer 1

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Valine ; Beta hemoglobin✔

In fact, it is the second base pair of codon 6 that is altered from an adenine base to a thymine base, resulted in coding for a valine.

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Answer 2

It can cause a missense mutation, which switches one amino acid in the chain for another. It can cause a nonsense mutation, which results in a shorter chain because of an early stop codon.

And a base substitution can also cause a silent mutation, in which the protein's function doesn't change at all.