Question

Single helically folded aromatic oligoamides that mimic the charge surface of double-stranded b-dna

Answer 1

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★·.·´¯`·.·★ ʸ̳ᵒ̳ᵘ̳ʳ̳ ̳ᵃ̳ⁿ̳ˢ̳ʷ̳ᵉ̳ʳ̳ ̳ⁱ̳ˢ̳ ★·.·´¯`·.·★

ᵗʰᵉ ʳᵉᵃˢᵒⁿ ⁱˢ...........

ᵇᵉⁱⁿᵍ ᶜᵒˡᵈ ᶜᵃⁿ ᵐᵃᵏᵉ ʸᵒᵘ ᵘʳⁱⁿᵃᵗᵉ ᵃ ˡⁱᵗᵗˡᵉ ᵐᵒʳᵉ - ʸᵒᵘʳ ᵇˡᵒᵒᵈ ᵛᵉˢˢᵉˡˢ ᵛᵃˢᵒᶜᵒⁿˢᵗʳⁱᶜᵗ ᵗᵒ ᵐᵃⁱⁿᵗᵃⁱⁿ ʷᵃʳᵐᵗʰ, ʷʰⁱᶜʰ ʸᵒᵘʳ ᵏⁱᵈⁿᵉʸˢ ˢᵉᵉ ᵃˢ ʰⁱᵍʰᵉʳ ᵇˡᵒᵒᵈ ᵖʳᵉˢˢᵘʳᵉ, ˢᵒ ᵗʰᵉʸ ᵈʳᵃʷ ᵒᵘᵗ ᵐᵒʳᵉ ᶠˡᵘⁱᵈ.

ʰᵒᵖᵉ ᵗʰⁱˢ ᵃⁿˢʷᵉʳ ʰᵉˡᵖˢ ʸᵒᵘ
ᵖˡᵉᵃˢᵉ ᵐᵃʳᵏ ⁱᵗ ᵃˢ ᵇʳᵃⁱⁿˡⁱᵉˢᵗ

Answer 2

Numerous essential biomolecular processes require the recognition of DNA surface features by proteins. Molecules mimicking these features could potentially act as decoys and interfere with pharmacologically or therapeutically relevant protein–DNA interactions. Although naturally occurring DNA-mimicking proteins have been described, synthetic tunable molecules that mimic the charge surface of double-stranded DNA are not known.