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Phosphofructokinase deficiency (PFK) is an inherited disease in this breed
The disease causes red blood cells to burst
(a) Explain why dogs with PFK find in difficult to exercise
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PFK is needed for glycolysis. The enzyme deficiency results in the accumulation of glycogen in the tissues. The enzyme deficiency can also lead to increased uric acid production and therefore possible gout. There may be a compensated haemolytic anaemia.
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