Spontaneous differentiation in pluripotent stem cells
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The discovery in 2006 that human and mouse fibroblasts could be reprogrammed to generate induced pluripotent stem cells (iPSCs) with qualities remarkably similar to embryonic stem cells has created a valuable new source of pluripotent cells for drug discovery, cell therapy, and basic research.
Our stem cell research products have been an integral part of induced pluripotent stem cell research research from the initial discovery of iPSCs to current breakthroughs. Our broad technology platform provides optimized tools for each step of the stem cell workflow: from reprogramming somatic cells to iPSC expansion, validation, and differentiation.
Answer:
Human embryonic stem cells and their spontaneous differentiation. ... A problem associated with ES cell culture is the spontaneous differentiation of cells into a variety of cell types representing all three germ layers, which is evident in both hESC colonies and hEBs.
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